Hydrogen Peroxide → Benzamide

HRID 485569Notes

Reaction equation

HRID 485569 reaction equation
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-:10].[Na+].OO>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.CO>[C:1]([NH2:8])(=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 7505BenzonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 2331BenzamideYield 96%

Reagents, catalysts & solvents 2

HCID 70681Tetrabutylammonium ChlorideCatalystHCID 887MethanolSolvent

Procedure

103.1 Grams of benzonitrile (II-4), 9.51 g of sodium methoxide, 291.5 g of a 35% aqueous hydrogen peroxide solution and 2.78 g of tetra-n-butylammonium chloride were mixed in 309.3 g of methanol. After the completion of the reaction, the formed precipitate was filtered out and washed with water to obtain 116.3 g of benzamide (m.p.: 130° C.) (I-4) in a yield of 96%.

Workup

  1. customAfter the completion of the reaction
  2. filtrationthe formed precipitate was filtered out
  3. washwashed with water

Sources & evidence

ORD record
ord-8f3d762f02524216b88920d0f8185b4b
Source dataset
uspto-grants-1985_08
Patent number
US04536599

Reaction notes

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