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HRID485632

反应详情

EQUATION

反应方程式

HRID 485632 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：CCCCCCCCCC(=O)O
HCID2969

Decanoic acid

C10H20O2

结构：C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2O
HCID9904

Nandrolone

C18H26O2

结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

PRODUCTS

生成物

1
结构：CCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C
HCID9677

Nandrolone decanoate

C28H44O3

收率 88.8%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：Cc1ccc(S(=O)(=O)O)cc1
催化剂HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

2 次

结构：CO.O
溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

To a stirred solution of 5,48 g 19-nortestosterone, 4 g decanoic acid, 0.24 g DMAP and 0.19 g pTSA in 35 ml CH2Cl2 is slowly added at 10° C. a solution of 5.6 g DCC in 30 ml CH2Cl2. After 5 h at room temperature 2 ml acetic acid is added. The same work-up procedure as in Example 6 gives 7.6 g of pure 19-nortestosterone decanoate (88% yield) as white crystals from methanol/water. M.P. 35°-36° C.