Sodium hydride → HCID 19097220, compound

HRID 486012Notes

Reaction equation

HRID 486012 reaction equation
[H-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([C:17]([O:19][N:20]([CH3:22])[CH3:21])=[O:18])=[C:12]([OH:16])[CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1.CS([C:27]1[N:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:29]([O:35][CH3:36])[N:28]=1)(=O)=O>CN(C)C=O>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:11]([C:17]([O:19][N:20]([CH3:22])[CH3:21])=[O:18])=[C:12]([O:16][C:27]3[N:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:29]([O:35][CH3:36])[N:28]=3)[CH:13]=[CH:14][CH:15]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidineHCID 19097218HCID 19097218, compound

Product 1

HCID 19097220HCID 19097220, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
30 °C

Procedure

At 10° C., 0.30 g (0.01 mol) of sodium hydride (80% strength) is added to a solution of 3.35 g (10 mmol) of 3-(4-bromophenyl)-2-(N,N-dimethylaminooxycarbonyl)-phenol in 25 ml of dried dimethylformamide, and the mixture is stirred for 3 hours at 30° C. Subsequently, 2.18 g (0.01 mol) of 2-methylsulfonyl-4,6-dimethoxypyrimidine is added and the mixture stirred for 12 hours at room temperature. Working up in accordance with Example 4 gives a colorless solid.

Workup

  1. stirringthe mixture stirred for 12 hours at room temperature
  2. customgives a colorless solid

Sources & evidence

ORD record
ord-20d699bfc4d14f6d88aa319512932139
Source dataset
uspto-grants-1994_03
Patent number
US05290755

Reaction notes

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