反应详情

1.75 g (10.8 mmol) of N,N'-carbonylbisimidazole is added to a solution of 2.12 g (10 mmol) of 6-(2-methylphenyl)-salicylic acid in 30 ml of tetrahydrofuran. After the mixture has been stirred for 30 minutes at room temperature 9.9 mmol of N-hydroxypyrazole is added and the mixture is stirred for a further 14 hours. The mixture is then hydrolyzed with 300 ml of 1N phosphoric acid and extracted several times with methyl tert-butyl ether. The organic phases are combined, dried over sodium sulfate and evaporated down under reduced pressure. The residue is taken up with 40 ml of dimethylformamide and 280 mg of sodium hydride (85% strength in paraffin, 10 mmol) is added. After the mixture has been stirred for 30 minutes at room temperature, 1.58 g (9 mmol) of 1-chloro-3,5-dimethoxy-s-triazine is added and the mixture stirred for 14 hours. It is then introduced into 300 ml of 0.1N phosphoric acid and extracted with diethyl ether. The ether phase is dried over sodium sulfate and evaporated down, and the residue is purified by column chromatography.

1. additionis added
2. extractionhydrolyzed with 300 ml of 1N phosphoric acid and extracted several times with methyl tert-butyl ether
3. dry with materialdried over sodium sulfate
4. customevaporated down under reduced pressure
5. additionis added
6. stirringAfter the mixture has been stirred for 30 minutes at room temperature
7. stirringthe mixture stirred for 14 hours
8. extractionextracted with diethyl ether
9. dry with materialThe ether phase is dried over sodium sulfate
10. customevaporated down
11. customthe residue is purified by column chromatography