反应详情

温度

80 °C

500 mg (1.35 mmol) of the compound of Example 6, 260 mg (1.59 mmol) of isatoic anhydride and 170 mg (1.39 mmol) of 4-dimethylaminopyridine were dissolved in 5 ml of dimethylformamide and the solution was stirred at 80° C. for 5 h. The solvent was distilled off under reduced pressure and ethyl acetate was added to the residue. A precipitate thus formed was recrystallized from ethanol to obtain 500 mg of the title compound.

1. distillationThe solvent was distilled off under reduced pressure and ethyl acetate
2. additionwas added to the residue
3. customA precipitate thus formed
4. customwas recrystallized from ethanol