Hydrochloric Acid → HCID 54060056, compound

HRID 486729Notes

Reaction equation

HRID 486729 reaction equation
[SH:1][C:2]([C@H:5]1[O:10][C:8](=[O:9])[C@@H:7]([CH2:11][SH:12])[CH2:6]1)([CH3:4])[CH3:3].Cl>C1COCC1.[OH-].[Na+]>[C:8]([C@@H:7]1[CH2:11][S:12][C@@H:5]([C:2]([SH:1])([CH3:4])[CH3:3])[CH2:6]1)([OH:10])=[O:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86747635HCID 86747635, compound

Product 1

HCID 54060056HCID 54060056, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14798Sodium HydroxideSolvent

Procedure

To a stirred solution of cis-4-(1-mercapto-1-methylethyl)-2-mercaptomethyl-4-butanolide (1.1 g) in THF (4 ml), 1N sodium hydroxide solution (5.2 ml) was added and the mixture was stirred for 30 minutes. The reaction mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give the titled compound (compound No. 8-1) quantitatively.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated sodium chloride solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c6db25ac4f3742329fe6a3f9316eea73
Source dataset
uspto-grants-1994_03
Patent number
US05292767

Reaction notes

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