Methanesulfonic Acid → HCID 88435121, compound

HRID 487034Notes

Reaction equation

HRID 487034 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12][S:13]([OH:16])(=[O:15])=[O:14].C(OCC)(=[O:19])C>>[CH3:12][S:13]([OH:16])(=[O:15])=[O:14].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][OH:19])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 8857Ethyl AcetateHCID 145334-Aminophenylacetic acid

Product 1

HCID 88435121HCID 88435121, compoundYield 98.5%

Procedure

The procedures of Example 8 were repeated, by substituting 3-amino-benzoic acid with 4-amino-phenyl-acetic acid (3 g: 0.0198 mole) and by using 19 g of CH3SO3H instead of 30 g, 2.2 g of H2O2 at 85% (0.055 mole) instead of 2.9 g, and ethyl acetate (300 moles) instead of THF. 5.2 g of crystalline and substantially pure 4-amino-phenyl-peracetic acid methanesulphonate were obtained. Yield: 98.5%.

Sources & evidence

ORD record
ord-899752f24ec0448587c66cbfd943a9c7
Source dataset
uspto-grants-1994_03
Patent number
US05294362

Reaction notes

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