Ethyl Acetate → HCID 136378379, compound

HRID 487066Notes

Reaction equation

HRID 487066 reaction equation
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:7](=[O:17])[C:8]3[C:13]([C:14]=2[N:15]=1)=[CH:12][CH:11]=[C:10]([Br:16])[CH:9]=3)=O.Cl.[NH2:19][OH:20].C(OCC)(=O)C.C(=O)(O)[O-].[Na+]>N1C=CC=CC=1>[N:19](=[CH:1][C:3]1[CH:4]=[CH:5][C:6]2[C:7](=[O:17])[C:8]3[C:13]([C:14]=2[N:15]=1)=[CH:12][CH:11]=[C:10]([Br:16])[CH:9]=3)[OH:20]

Participants

6

Reactant 4

HCID 8857Ethyl AcetateHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 19093474HCID 19093474, compound

Product 1

HCID 136378379HCID 136378379, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 286 mg (1 mmole) of 3-formyl-7-bromo-4-aza-9-fluorenone (prepared as described in Example 42), 85 mg (1.2 mmole) of hydroxylamine hydrochloride in ~2 mL of pyridine is stirred overnight at R.T. Ethyl acetate and excess sodium bicarbonate solution are then added and the precipitated solid precipitate is filtered and dried to give 3-oximinomethyl-7-bromo-4-aza-9-fluorenone.

Workup

  1. filtrationthe precipitated solid precipitate is filtered
  2. customdried

Sources & evidence

ORD record
ord-2abf25df6b154003a31e90f16d03bda7
Source dataset
uspto-grants-1994_03
Patent number
US05294610

Reaction notes

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