Methanol → HCID 19014038, compound

HRID 487524Notes

Reaction equation

HRID 487524 reaction equation
C([O-])(=O)C.[K+].[CH3:6][S:7]([NH:10][C:11]1[CH:24]=[CH:23][C:14]([C:15]([CH2:17][C:18]([O:20]CC)=[O:19])=O)=[CH:13][CH:12]=1)(=[O:9])=[O:8].Cl.[NH2:26]O.CO>O>[CH3:6][S:7]([NH:10][C:11]1[CH:24]=[CH:23][C:14]([C:15]2[CH2:17][C:18](=[O:19])[O:20][N:26]=2)=[CH:13][CH:12]=1)(=[O:9])=[O:8]

Participants

6

Reactant 4

HCID 887MethanolHCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 13971553HCID 13971553, compound

Product 1

HCID 19014038HCID 19014038, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium acetate (8.2 g) was added to a mixture of ethyl 4-methanesulfonamidobenzoylacetate (23.0 g), hydroxylamine hydrochloride (5.8 g) and methanol (35 ml), and the mixture was heated for refluxing for 30 minutes. The reaction mixture was poured into water (210 ml) to filter off the deposited crystals and dry them, whereby 3-(4-methanesulfonamidophenyl)isoxazoline-5-one (11.3 g) was obtained.

Workup

  1. temperaturethe mixture was heated
  2. temperaturefor refluxing for 30 minutes
  3. filtrationto filter off the deposited crystals
  4. customdry them

Sources & evidence

ORD record
ord-9432ff8f81fc41b19ea7a13ea9c51c00
Source dataset
uspto-grants-1994_03
Patent number
US05296344

Reaction notes

Loading…