Propylamine → HCID 14995355, compound

HRID 487552Notes

Reaction equation

HRID 487552 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].C(N(CC)CC)C.Br[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=2[CH:25]=1>CN(C)C=O>[CH2:1]([NH:4][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=2[CH:25]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 8471TriethylamineHCID 14995354HCID 14995354, compound

Product 1

HCID 14995355HCID 14995355, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a round-bottomed flask equipped with a mechanical stirrer and a calcium chloride guard tube, 0.01 mol of n-propylamine and 0.015 mol of triethylamine are added to a solution of 6-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine in 40 cm3 of dimethylformamide. The mixture is heated to reflux for 15 hours and the precipitate formed is drained in the heated state. The residue is evaporated under vacuum and the product is recrystallized.

Workup

  1. customIn a round-bottomed flask equipped with a mechanical stirrer and a calcium chloride guard tube
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 15 hours
  4. customthe precipitate formed
  5. customThe residue is evaporated under vacuum
  6. customthe product is recrystallized

Sources & evidence

ORD record
ord-0ee7a27273a34b79ad7caa72649fd72b
Source dataset
uspto-grants-1994_03
Patent number
US05296477

Reaction notes

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