反应详情

A mixture of 2.5 g (5.95 mmol) of 2-hydroxy-5-(octadecyloxy)benzoic acid methyl ester, 0.78 ml (6.54 mmol) of benzyl bromide and 4.1 g (29.8 mmol) of potassium carbonate in 100 ml of acetone and 10 ml of DMF was stirred at reflux under an argon atmosphere for 24 hours. The solvent was removed at reduced pressure and the residue was treated with water. The product was extracted with ethyl ether and the dried extract was concentrated to a solid which was purified by HPLC using 5% ethyl acetate-hexane to give 2.5 g (82% yield, mp 52°-54°) of 5-(octadecyloxy)-2-(phenylmethoxy)benzoic acid methyl ester.

1. temperatureat reflux under an argon atmosphere for 24 hours
2. customThe solvent was removed at reduced pressure
3. additionthe residue was treated with water
4. extractionThe product was extracted with ethyl ether
5. extractionthe dried extract
6. concentrationwas concentrated to a solid which
7. customwas purified by HPLC