反应详情

A mixture of o-bromobenzoic acid potassium salt (47.8 g, 0.2 mol), 4-iodoaniline (43.8 g, 0.2 mol), K2CO3 (13.8 g, 0.1 mol), and cupric acetate (2.87 g, 6%) in diglyme (100 mL) was heated to reflux for 30 minutes. The reaction mixture was diluted with H2O (1.0 L) and filtered. The filtrate was acidified with diluted AcOH. The resulting precipitate was collected by filtration, washed with H2O and dried in a vacuum at 50° C. for 16 hours. Recrystallization from EtOAc gave the desired product, a solid (29.7 g, 0.087 mol, 44%). mp 205-206° C.

1. temperaturewas heated
2. temperatureto reflux for 30 minutes
3. filtrationfiltered
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with H2O
6. customdried in a vacuum at 50° C. for 16 hours
7. customRecrystallization from EtOAc