反应详情

温度

20 °C

A solution of sodium azide (4.70 g) in degassed water (25 ml) was added to a solution of (1R,4S)-4-hydroxy-2-cyclopenten-1-yl acetate (9.99 g) in tetrahydrofuran (60 ml) and stirred for 10 min. Tetrakis(triphenylphosphine)palladium(0) (365 mg) was added and stirred for 10 min. The aqueous layer was separated and extracted twice with ethyl acetate. The combined organic layers were dried (MgSO4), concentrated and purified on a short column (SiO2, ethyl acetate:isohexane 1:2 as eluant) to afford a yellow oil. This was dissolved in tetrahydrofuran (25 ml) and slowly added to a suspension of sodium hydride (2.94 g, 60% dispersion in oil) in tetrahydrofuran (60 ml) at −78° C. A solution of ethyl bromoacetate (8.2 ml) in tetrahydrofuran (5 ml) was added and the mixture was allowed to warm to 20° C. and stirred for 30 min. Aqueous ammonium chloride solution was added and the mixture was extracted with ether. The organic layers were dried (MgSO4), concentrated and purified (SiO2, ether:isohexane 1:5 as eluant) to afford a colourless oil. A solution of this oil and triphenylphosphine (17.89 g) in tetrahydrofuran (90 ml) was stirred for 10 min. Water (15 ml) was added and the solution was stirred for 18 hours. The solvent was removed in vacuo and the residue azeotroped with toluene then purified (SiO2, ethyl acetate then ethyl acetate-methanol-ammonia (90:9:1) as eluant) to afford a pale yellow oil (7.14 g).

1. stirringstirred for 10 min
2. customThe aqueous layer was separated
3. extractionextracted twice with ethyl acetate
4. dry with materialThe combined organic layers were dried (MgSO4)
5. concentrationconcentrated
6. custompurified on a short column (SiO2, ethyl acetate:isohexane 1:2 as eluant)
7. customto afford a yellow oil
8. stirringstirred for 30 min
9. extractionthe mixture was extracted with ether
10. dry with materialThe organic layers were dried (MgSO4)
11. concentrationconcentrated
12. custompurified (SiO2, ether:isohexane 1:5 as eluant)
13. customto afford a colourless oil
14. stirringthe solution was stirred for 18 hours
15. customThe solvent was removed in vacuo
16. customthe residue azeotroped with toluene
17. customthen purified (SiO2, ethyl acetate