Hydrochloric Acid → HCID 69140350, compound

HRID 489649Notes

Reaction equation

HRID 489649 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:29]C(OC(C)(C)C)=O)[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1.Cl>CCOC(C)=O>[NH2:29][C@H:9]([CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[NH:24][S:25]([CH3:28])(=[O:26])=[O:27])[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23587436HCID 23587436, compound

Product 1

HCID 69140350HCID 69140350, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Step (e) using N-[(1R)-1-[(4-chlorophenyl)methyl]-2-(4-{2-[(methylsulfonyl)-amino]phenyl}piperidyl)-2-oxoethyl](tert-butoxy)-carboxamide (Step f) (250 mg, 0.50 mmol) and a saturated soln of HCl in EtOAc (10 mL). The title compound (HCl salt) was isolated by filtration as a white solid (195 mg, 83%). MS (ESI, pos. ion) m/z: 473 (M+1). Calc'd for C21H27Cl2N3O3S: 472.43.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d22a8bc827cf4b75aff8d3d38f4a8acc
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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