反应详情

To a mixture of 3-[3-(3-hydroxy-2-thienyl)-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)uracil(0.580 g, 1.36 mmol) in dimethylformamide is added potassium carbonate (0.230 g, 1.66 mmol). The resultant mixture is stirred 30 minutes and treated with methyl bromoacetate (0.230 g, 1.50 mmol). The mixture is stirred over a weekend at room temperature and poured into water. Filtration and drying affords the title compound as an off-white solid (0.550 g, 81.4%, mp 73-79° C.) which is identified by NMR spectral analysis.

1. filtrationFiltration
2. customdrying