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HRID489670

反应详情

EQUATION

反应方程式

HRID 489670 的结构方程式

REACTANTS

反应物

5
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：On1nnc2cccnc21
HCID181649

3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-

C5H4N4O

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)O
HCID7018791

Boc-4-chloro-D-phenylalanine

C14H18ClNO4

结构：Cl.FC(F)(F)c1ccccc1C1CCNCC1
HCID21936970

4-[2-(Trifluoromethyl)phenyl]piperidine--hydrogen chloride (1/1)

C12H15ClF3N

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccccc2C(F)(F)F)CC1
HCID69151295

未命名化合物

收率 69.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1 (Step f) from 4-[2-(trifluoromethyl)phenyl]piperidine hydrochloride (Step c) (0.792 g, 3.0 mmol), DIEA (0.54 mL, 3.0 mmol), Boc-p-Cl-D-PheOH (PepTech Corporation) (1.36 g, 4.5 mmol), HOAT (Aldrich) (0.615 g, 4.5 mmol) and EDC (Aldrich) (0.864 g, 4.5 mmol) in DMF (5 mL). Purification by silica gel chromatography (5:2 hexane:EtOAc) provided the title compound as a white foam (1.06 g). MS (ESI, pos. ion) m/z: 511 (M+1); MS (ESI, neg. ion) m/z: 509 (M−1). Calc'd for C26H30ClF3N2O3: 510.98.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customPurification by silica gel chromatography (5:2 hexane:EtOAc)