Hydrochloric Acid → HCID 69141554, compound

HRID 489676Notes

Reaction equation

HRID 489676 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:27]C(OC(C)(C)C)=O)[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH2:24][CH2:25][OH:26])[CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1.Cl>CCOC(C)=O>[ClH:1].[NH2:27][C@H:9]([CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:24][CH2:25][OH:26])[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23587433HCID 23587433, compound

Product 1

HCID 69141554HCID 69141554, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1 (Step e) using N-((1R)-1-[(4-chlorophenyl)methyl]-2-(4-[2-(hydroxyethyl)phenyl]piperidyl)-2-oxoethyl)(tert-butoxy)carboxamide (Step d) (0.976 g, 2.0 mmol) and satd anhydrous HCl in EtOAc (30 mL). The title compound was obtained as a white solid (0.846 g). MS (ESI, pos. ion) m/z: 387 (M+1) MS (EST, neg. ion) m/z: 385 (M−1). Calc'd for C22H27ClN2O2: 386.18.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-50f23db0eb0846fc890c44aa89fa2824
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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