Hydrochloric Acid → HCID 69140498, compound

HRID 489683Notes

Reaction equation

HRID 489683 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][N:14]([S:46]([CH3:49])(=[O:48])=[O:47])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH:21]1[CH2:26][CH2:25][N:24]([C:27](=[O:45])[C@H:28]([NH:37]C(OC(C)(C)C)=O)[CH2:29][C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=2)[CH2:23][CH2:22]1.Cl>CCOC(C)=O>[ClH:36].[NH2:37][C@H:28]([CH2:29][C:30]1[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=1)[C:27]([N:24]1[CH2:23][CH2:22][CH:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[N:14]([S:46]([CH3:49])(=[O:47])=[O:48])[CH2:13][CH2:12][N:3]2[C:4](=[O:11])[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:2]2=[O:1])[CH2:26][CH2:25]1)=[O:45]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69151723HCID 69151723, compound

Product 1

HCID 69140498HCID 69140498, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in (Step b) from N-((1R)-2-[4-(2-{[2-(1,3-dioxoisoindolin-2-yl)ethyl] (methylsulfonyl)-amino}phenyl)-piperidyl]-1-[(4-chlorophenyl)methyl]-2-oxoethyl}(tert-butoxy)carboxamide (Step c) (1.77 g, 2.5 mmol) and satd anhydrous HCl in EtOAc (50 mL). The title compound was obtained as a white solid (1.61 g). MS (ESI, pos. ion) m/z: 609 (M+1); MS (ESI, neg. ion) m/z: 607 (M−1). Calc'd for C31H14Cl2N4O5S: 645.60.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-64c138380ede43c296d13d57b85cef29
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

Loading…