Hydrochloric Acid → HCID 23587439, compound

HRID 489696Notes

Reaction equation

HRID 489696 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:42]C(OC(C)(C)C)=O)[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][C:25]([O:27][CH2:28][CH:29]3[C:41]4[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=4[C:35]4[C:30]3=[CH:31][CH:32]=[CH:33][CH:34]=4)=[O:26])[CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1.Cl>CCOC(C)=O>[ClH:1].[NH2:42][C@H:9]([CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[NH:24][C:25]([O:27][CH2:28][CH:29]2[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:35]=3[C:36]3[C:41]2=[CH:40][CH:39]=[CH:38][CH:37]=3)=[O:26])[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23587432HCID 23587432, compound

Product 1

HCID 23587439HCID 23587439, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 16 (Step b) from N-[(1R)-1-[(4-chlorophenyl)methyl]-2-(4-{2-[(fluoren-9-ylmethoxy)carbonylamino]-phenyl}piperidyl)-2-oxoethyl](tert-butoxy)carboxamide (Step c) (6.8 g, 10 mmol) and satd anhydrous HCl in EtOAc (50 mL). The title compound was obtained as a white solid (6.1 g). MS (ESI, pos. ion) m/z: 580 (M+1); MS (ESI, neg. ion) m/z: 578 (M−1). Calc'd for C35H35Cl2N3O3: 579.23.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9394d04d8493464cb496d8a20d257d6e
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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