Potassium Cyanide → HCID 68675848, compound

HRID 491103Notes

Reaction equation

HRID 491103 reaction equation
[C-:1]#[N:2].[K+].[O:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1.[CH2:11]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>Cl.O>[CH2:11]([N:18]1[CH2:23][CH2:22][N:21]([C:7]2([C:1]#[N:2])[CH2:8][CH2:9][O:4][CH2:5][CH2:6]2)[CH2:20][CH2:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

6

Reactant 3

HCID 9032Potassium CyanideHCID 759941-BenzylpiperazineHCID 121599Tetrahydro-4H-pyran-4-one

Product 1

HCID 68675848HCID 68675848, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

6.5 g (99.8 mmol) potassium cyanide were added to a solution of 10.0 g (96.9 mmol) tetrahydropyran-4-one and 17.1 g (97.0 mmol) 1-benzyl-piperazine in 25 mL 4 M HCl and 50 mL water while cooling with ice and the reaction mixture was stirred for 40 h at RT. The precipitate formed was suction filtered, washed with water and dried.

Workup

  1. temperaturewhile cooling with ice
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-59de51da636b4f30aa7455377ddcc7bc
Source dataset
uspto-grants-2009_05
Patent number
US07528129B2

Reaction notes

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