Hydrochloric Acid → 8-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride

HRID 491476Notes

Reaction equation

HRID 491476 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C:10]2([CH2:17][CH2:16][N:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH2:14][CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[CH3:21][S:18]([N:15]1[CH2:14][CH2:13][C:10]2([CH2:9][NH:8][CH2:12][CH2:11]2)[CH2:17][CH2:16]1)(=[O:19])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 666627142,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester

Product 1

HCID 179736148-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 8-methanesulfonyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (1.32 g) in ethyl acetate (10 ml), a 1 M ethyl acetate solution of HCl (20 ml). After stirring for 2 h at room temperature, solvent is evaporated down to give 8-methanesulfonyl-2,8-diaza-spiro[4.5]decane hydrochloride as a solid.

Workup

  1. customsolvent is evaporated down

Sources & evidence

ORD record
ord-f381f29da1b04360a20fc8de696f5d2b
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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