反应详情

To a solution of 4′-fluoroacetophenone (5 g, 36.2 mmol) in propan-2-ol (90 ml) was added paraformaldehyde (4.35 g, 0.145 mol), dimethylamine hydrochloride (54.2 mmol) and concentrated HCl (0.8 ml). The reaction was heated at reflux for 18 h and on cooling the solvent was removed in vacuo. The residue was treated with acetone giving a white precipitate which was collected by filtration and dried in vacuo to give the title compound as a white solid (7.9 g). MS (ES): MH+ 196.

1. temperatureThe reaction was heated
2. temperatureat reflux for 18 h
3. temperatureon cooling the solvent
4. customwas removed in vacuo
5. additionThe residue was treated with acetone giving a white precipitate which
6. filtrationwas collected by filtration
7. customdried in vacuo