Hydrochloric Acid → HCID 67023471, compound

HRID 491875Notes

Reaction equation

HRID 491875 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH:4]([N:14](C(OC(C)(C)C)=O)[CH3:15])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[ClH:24]>ClCCl.C(O)(C)C>[ClH:24].[CH3:1][O:2][C:3](=[O:23])[CH:4]([NH:14][CH3:15])[CH2:5][O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67023672HCID 67023672, compound

Product 1

HCID 67023471HCID 67023471, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-propionic acid methyl ester (0.6 g, 1.86 mmol) was dissolved in dichloromethane and then added slowly into a mixture of hydrochloric acid in isopropyl alcohol ([5M], 3 mL). The reaction mixture was stirred for 2 hours at room temperature. The solvent was then evaporated and the residue was kept on high vacuum atmosphere overnight to yield a crude product as an oil. The crude product was stored in the freezer as an oil.

Workup

  1. customThe solvent was then evaporated
  2. customwas kept on high vacuum atmosphere overnight

Sources & evidence

ORD record
ord-cc4ffcb35999405781942816c728022b
Source dataset
uspto-grants-2009_05
Patent number
US07531545B2

Reaction notes

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