反应详情

温度

0 °C

Sodium hydride (3.18 g; 0.0795 mol of a powder dispersed at 60%) is added at 23° C. to a solution containing 4-(2-hydroxyethyl)morpholine (9.40 g, 0.072 mol) in dimethylformamide (60 ml). Stirring is maintained for 30 minutes then the compound 4-fluoroacetophenone (5 g, 0.0362 mol) is added. The reaction medium is stirred for one hour at 23° C. then cooled down to 0° C. and water is added. After the addition of ethyl acetate then extraction, the organic phase is washed with a saturated sodium chloride solution, dried over sodium sulphate then the solvent is evaporated off. The residue obtained is adsorbed on silica then purified by chromatography on a Biotage-type silica column (eluent: ethyl acetate-heptane: 6-1). An orange-coloured oil is obtained.

1. additionis added at 23° C. to a solution
2. temperatureis maintained for 30 minutes
3. stirringThe reaction medium is stirred for one hour at 23° C.
4. extractionextraction
5. washthe organic phase is washed with a saturated sodium chloride solution
6. dry with materialdried over sodium sulphate
7. customthe solvent is evaporated off
8. customThe residue obtained
9. customthen purified by chromatography on a Biotage-type silica column (eluent: ethyl acetate-heptane: 6-1)
10. customAn orange-coloured oil is obtained