反应详情

温度

60 °C

First, 2.73 g of 2-methoxyphenol and 5.5 g of potassium carbonate were added to 20 ml of N,N-dimethylformamide, and the temperature was increased to 60° C. To the mixture was added dropwise a solution consisting of 4.3 g of N-(2,5-difluoro-4-nitrophenyl)acetamide and 30 ml of N,N-dimethylformamide at a temperature of 60° C. to 65° C. After stirring while keeping the temperature for 1 hour, the mixture was cooled to room temperature and then poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with diluted hydrochloric acid and water, dried over magnesium sulfate, and then concentrated to give 5.52 g of N-[2-fluoro-5-(2-methoxyphenoxy)-4-nitrophenyl]acetamide.

1. additionTo the mixture was added dropwise a solution
2. customfor 1 hour
3. temperaturethe mixture was cooled to room temperature
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic layer was washed with diluted hydrochloric acid and water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated