Hydrochloric Acid → HCID 68829620, compound

HRID 494302Notes

Reaction equation

HRID 494302 reaction equation
[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[C:21]#[N:22])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1.[ClH:23]>CCOC(C)=O>[ClH:23].[N:1]1([CH2:6][C@H:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][CH2:13][C:14]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[C:21]#[N:22])=[O:15])[CH2:8]2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11673866HCID 11673866, compound

Product 1

HCID 68829620HCID 68829620, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a stirred solution of Example 37 (100 mg, 0.30 mmol) in EtOAc (3 ml) was added a saturated solution of dry HCl in EtOAc (2 ml). This solution was stirred at RT for 30 min to result a white precipitate. The product was collected by filtration and dried under vacuum to give 112 mg of the product as a white solid; 1H NMR (D2O, 300 MHz) δ 1.44-1.64 (m, 2H), 1.81-2.06 (m, 2H), 2.11-2.37 (m, 7H), 2.60-2.62 (m, 1H), 3.45-3.77 (m, 4H), 4.18-4.38 (m, 2H), 4.40-4.44 (m, 2H), 8.52 (s, 1H), 9.23 (s, 1H).

Workup

  1. customto result a white precipitate
  2. filtrationThe product was collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-c4ac5fd28acf4313940e2428a58b9d57
Source dataset
uspto-grants-2009_05
Patent number
US07538128B2

Reaction notes

Loading…