反应详情

温度

140 °C

19.5 g of 3-nitro-4-methylbenzamide and 30 g of dimethylformamide dimethyl acetal were dissolved in 200 ml of dimethylformamide. The obtained mixture was stirred at 140° C. for 20 hours. The mixture was then concentrated under a reduced pressure. Thereafter, 360 ml of methanol and 25 g of chlorotrimethylsilane were added to the residue. The obtained solution was heated to reflux for 16 hours. The reaction solution was cooled and then concentrated under a reduced pressure. Water and ethyl acetate were added thereto, so as to divide an organic layer. The organic layer was separated, and then washed with a saturated sodium bicarbonate aqueous solution and a saturated sodium chloride solution. It was then dried over anhydrous magnesium sulfate. The mixture was filtered through 100 g of a silica gel layer, and then washed with ethyl acetate. Thereafter, the filtrate was concentrated under a reduced pressure. 0.9 g of 10% palladium carbon was added to 150 ml of a methanol solution containing the obtained crude product, and the mixture was intensively stirred in a hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated under a reduced pressure. The obtained residue was purified by NH silica gel column chromatography (hexane/ethyl acetate), so as to obtain 11.5 g of the subject compound.

1. concentrationThe mixture was then concentrated under a reduced pressure
2. additionThereafter, 360 ml of methanol and 25 g of chlorotrimethylsilane were added to the residue
3. temperatureThe obtained solution was heated
4. temperatureto reflux for 16 hours
5. temperatureThe reaction solution was cooled
6. concentrationconcentrated under a reduced pressure
7. additionWater and ethyl acetate were added
8. customThe organic layer was separated
9. washwashed with a saturated sodium bicarbonate aqueous solution
10. dry with materialIt was then dried over anhydrous magnesium sulfate
11. filtrationThe mixture was filtered through 100 g of a silica gel layer
12. washwashed with ethyl acetate
13. concentrationThereafter, the filtrate was concentrated under a reduced pressure
14. addition0.9 g of 10% palladium carbon was added to 150 ml of a methanol solution
15. additioncontaining the
16. customobtained crude product
17. customAfter completion of the reaction
18. customthe catalyst was removed by filtration
19. concentrationthe filtrate was concentrated under a reduced pressure
20. customThe obtained residue was purified by NH silica gel column chromatography (hexane/ethyl acetate)