反应详情

5.00 g of 2′-hydroxy-4′-methoxyacetophenone was dissolved in 40 ml of N,N-dimethylformamide at room temperature. Thereafter, 4.16 g of potassium carbonate and 2.80 ml of allyl bromide were successively added to the reaction solution. After the disappearance of materials had been confirmed, water and ethyl acetate were added to the reaction solution, so as to separate an organic layer. The obtained organic layer was washed with water and a saturated sodium chloride aqueous solution, and then dried over anhydrous magnesium sulfate. After removing the drying agent by filtration, the organic layer was concentrated under a reduced pressure, and the residue was then purified by silica gel column chromatography (hexane/ethyl acetate), so as to obtain 5.60 g of the subject compound.

1. customso as to separate an organic layer
2. washThe obtained organic layer was washed with water
3. dry with materiala saturated sodium chloride aqueous solution, and then dried over anhydrous magnesium sulfate
4. customAfter removing the drying agent
5. filtrationby filtration
6. concentrationthe organic layer was concentrated under a reduced pressure
7. customthe residue was then purified by silica gel column chromatography (hexane/ethyl acetate)