反应详情

温度

0 °C

A solution of 2.85 g sertraline free amine (obtained after treating a solution of sertraline mandelate salt in ethyl acetate with a 2 molar solution of NaOH in water, followed by a standard organic work-up procedure) in 300 ml diethyl ether is cooled to 0° C. At this temperature, gaseous HCl is introduced in the reaction mixture for 30 minutes. The reaction mixture, a white suspension, is warmed to room temperature and stirred overnight under an argon atmosphere. The white suspension is filtered and the white product washed with diethyl ether (3×50 ml). The resulting white solid is dried at room temperature by blowing gently a stream of air over the product.

1. temperatureThe reaction mixture, a white suspension, is warmed to room temperature
2. filtrationThe white suspension is filtered
3. washthe white product washed with diethyl ether (3×50 ml)
4. customThe resulting white solid is dried at room temperature