反应详情

温度

70 °C

To a mixture of 3,5-difluoro-6-nitrophenol (100 mg, 0.571 mmol) and potassium carbonate (394 mg) in DMF (5 ml) was added epibromohydrin (80 mg, 0.582 mmol) and was stirred at 70° C. for 3 hr. Water and ethyl acetate were added, the organic phase separated, dried and concentrated. The resulting residue was purified by chromatography (ethyl acetate:heptan 1:3) to give the desired product as a solid 161 mg (0.696 mmol).

1. customthe organic phase separated
2. customdried
3. concentrationconcentrated
4. customThe resulting residue was purified by chromatography (ethyl acetate:heptan 1:3)