Triethylamine → HCID 140382079, compound

HRID 496827Notes

Reaction equation

HRID 496827 reaction equation
N[C:2]1[C:6]([CH2:7][C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)=[CH:5][NH:4][C:3]=1[C:13]([O:15][CH3:16])=[O:14].[C:17]([NH:21][C:22](=[N:25][C:26]([O:28][CH3:29])=[O:27])SC)([O:19][CH3:20])=[O:18].C([N:32](CC)CC)C>CN(C)C=O>[C:26]([N:25]([C:2]1[C:6]([CH2:7][C:8]2[CH:12]=[CH:11][S:10][CH:9]=2)=[CH:5][NH:4][C:3]=1[C:13]([O:15][CH3:16])=[O:14])[C:22]([NH:21][C:17]([O:19][CH3:20])=[O:18])=[NH:32])([O:28][CH3:29])=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 98708Methyl [[(methoxycarbonyl)amino](methylthio)methylene]carbamateHCID 10263505HCID 10263505, compound

Product 1

HCID 140382079HCID 140382079, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
5 °C

Procedure

Methyl 3-amino-4-(3-thienylmethyl)-1H-pyrrole-2-carboxylate, obtained from Example 14 (11.8 g, 0.05 mol), N,N′-bis-carbomethoxy-S-methylisothiourea (11.3 g, 0.055 mol) and triethylamine were stirred together in dimethyl formamide (100 mL) and cooled to 5° C. Mercuric chloride (14.9 g, 0.055 mol) was added and an immediate precipitate was observed. The mixture was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-1c97259a2d464ec4acd8dda035eaa939
Source dataset
uspto-grants-2005_09
Patent number
US06946554B2

Reaction notes

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