反应详情

Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.

1. temperatureThe solution was heated
2. temperatureat reflux
3. stirringto stir under N2 for 15 minutes
4. washwashed with water
5. extractionThe organic extract
6. dry with materialwas dried (MgSO4)
7. customevaporated in vacuo