反应详情

11 cm3 of tetrabutylammonium fluoride as a 1M solution in tetrahydrofuran are added to 800 mg of N-[6-chloro-5-(3-furyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide, described previously, in 30 cm3 of tetrahydrofuran, and the mixture is refluxed for 18 hours. The reaction medium is diluted with 75 cm3 of ethyl acetate and 50 cm3 of saturated sodium hydrogen carbonate solution. The organic phase is separated out after settling of the phases has taken place, washed with 50 cm3 of saturated sodium chloride solution, dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50° C.). The crude product obtained is purified by chromatography under an argon pressure of 50 kPa, on a column of silica gel (particle size 40-60 μm; diameter 2.5 cm), eluting with a cyclohexane/ethyl acetate mixture (50/50 by volume). The fractions containing the expected product are combined and evaporated under reduced pressure (2 kPa; 50° C.); the residue is taken up in 25 cm3 of diethyl ether, filtered off, washed with 2×10 cm3 of diethyl ether and dried under reduced pressure (90 Pa; 45° C.) to give 220 mg of N-[6-chloro-5-(3-furyl)-1H-indazol-3-yl]butanamide in the form of white crystals melting at 250° C.

1. temperaturethe mixture is refluxed for 18 hours
2. customThe organic phase is separated out
3. washwashed with 50 cm3 of saturated sodium chloride solution
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated to dryness under reduced pressure (2 kPa; 50° C.)
7. customThe crude product obtained
8. customis purified by chromatography under an argon pressure of 50 kPa
9. washon a column of silica gel (particle size 40-60 μm; diameter 2.5 cm), eluting with a cyclohexane/ethyl acetate mixture (50/50 by volume)
10. additionThe fractions containing the expected product
11. customevaporated under reduced pressure (2 kPa; 50° C.)
12. filtrationfiltered off
13. washwashed with 2×10 cm3 of diethyl ether
14. customdried under reduced pressure (90 Pa; 45° C.)