Bromoacetic Acid → HCID 22320730, compound

HRID 498072Notes

Reaction equation

HRID 498072 reaction equation
[Br:1][CH2:2][C:3]([OH:5])=O.[CH2:6]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N=C=NC(C)C)(C)C>>[CH2:6]([CH:13]1[CH2:18][CH2:17][N:16]([C:3](=[O:5])[CH2:2][Br:1])[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 6227Bromoacetic AcidHCID 12734DiisopropylcarbodiimideHCID 317384-Benzylpiperidine

Product 1

HCID 22320730HCID 22320730, compound

Procedure

Prepared as stated above for compound (22) from bromo acetic acid (935mg, 6.78 mmol) and 4-benzyl piperdine (1.02 g, 5.82 mmol) and diisopropylcarbodiimide (856 mg, 6.78 mmol) to afford compound 23, 1.53 g, (89%), (MH+) m/z 297.88.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-251dffb3298f4890b395670388d8d31c
Source dataset
uspto-grants-2005_09
Patent number
US06949655B2

Reaction notes

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