Hydrochloric Acid → 1-(4-Methoxyphenyl)-4-(2-phenylethoxy)-1-butanone

HRID 498149Notes

Reaction equation

HRID 498149 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)OCC[O:11]2)=[CH:6][CH:5]=1.CCCCCCC.CCOCC>C1COCC1>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10](=[O:11])[CH2:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21897273Diethylether heptaneHCID 223208922-(4-Methoxyphenyl)-2-[3-(2-phenylethoxy)propyl]-1,3-dioxolane

Product 1

HCID 223208981-(4-Methoxyphenyl)-4-(2-phenylethoxy)-1-butanoneYield 78%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was synthesized as described under 5.c) with 0.8 ml of HCl (1N) and 0.65 g (1.9 mmol) of 2-(4-methoxyphenyl)-2-[3-(2-phenylethoxy)propyl]-1,3-dioxolane obtained under a) in 50 ml of THF. Column chromatography (SiO2, heptane/ether 4:1) gave 0.44 g (78%) of white crystals.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-dabe647cdaeb467188cb6f212d05ffa7
Source dataset
uspto-grants-2005_09
Patent number
US06949680B2

Reaction notes

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