HCID 59420839, compound → 7-Mercapto-2-(2,2,2-trifluoroethyl)-1(2H)-isoquinolinone

HRID 499101Notes

Reaction equation

HRID 499101 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([S:14][Si](C(C)C)(C(C)C)C(C)C)=[CH:9][CH:10]=2)[C:5]1=[O:25]>Cl.CO.O1CCCC1>[F:27][C:2]([F:1])([F:26])[CH2:3][N:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([SH:14])=[CH:9][CH:10]=2)[C:5]1=[O:25]

Participants

5

Reactant 1

HCID 59420839HCID 59420839, compound

Product 1

HCID 594208437-Mercapto-2-(2,2,2-trifluoroethyl)-1(2H)-isoquinolinone

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

2-(2,2,2-trifluoroethyl)-7-((triisopropylsilyl)sulfanyl)isoquinolin-1(2H)-one was dissolved in a solution of hydrochloric acid in methanol (2 ml) and tetrahydrofuran (2 ml) and stirred at room temperature for 2 hours or until disappearance of starting material. Reaction mixture was concentrated to give the desired material (quant yield).

Workup

  1. customReaction mixture
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-6473e2cdfc824cc1af5e2a3631d04e4e
Source dataset
uspto-grants-2010_08
Patent number
US07767672B2

Reaction notes

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