反应详情

To solution of 2-fluoro-4-iodoaniline (9.21 g, 38.86 mmol) and 3,6-Dichloro-pyridazine-4-carboxylic acid (10.84 g, 64.77 mmol) in THF (80 mL) at −78° C., was added LiHMDS (5 g, 25.91 mmol). The mixture was allowed to warm to room temperature and stirred for 12 h. The mixture as diluted with ethyl acetate and washed with H2O and brine. The organic layer was dried with solid Na2SO4 and was concentrated. The resulting residue was purified by flash chromatography in silica (25% ethyl acetate-hexane) to give pure product. LC/MS [4.52 min; 394 (M+1)].

1. washwashed with H2O and brine
2. dry with materialThe organic layer was dried with solid Na2SO4
3. concentrationwas concentrated
4. customThe resulting residue was purified by flash chromatography in silica (25% ethyl acetate-hexane)
5. customto give pure product
6. customLC/MS [4.52 min; 394 (M+1)]