Dichloromethane → N-((3-chloropyrazin-2-yl)methyl)-3-methylenecyclobutanecarboxamide
Reaction equation
CCN=C=[N:5][CH2:6][CH2:7][CH2:8][N:9]([CH3:11])C.C([N:14]([CH:18](C)C)C(C)C)C.[CH2:21]=[C:22]1[CH2:25][CH:24]([C:26]([OH:28])=O)[CH2:23]1.C(Cl)[Cl:30]>CN(C1C=CN=CC=1)C>[Cl:30][C:8]1[C:7]([CH2:6][NH:5][C:26]([CH:24]2[CH2:23][C:22](=[CH2:21])[CH2:25]2)=[O:28])=[N:14][CH:18]=[CH:11][N:9]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
EDCI (13.47 g, 70 mmol), DMAP (1.19 g, 9.8 mmol) and EXAMPLE 283A (12.5 g, 58 mmol) in CH2Cl2 (300 mL) were treated with ethyldiisopropyl amine (20 mL, 170 mmol) and 3-methylene-cyclobutanecarboxylic acid (Caserio et al. J. Am. Chem. Soc. 1958, 80, 5507)(6.59 g, 59 mmol). After 8 h at ambient temperature, an additional 2.88 g of EDCI was added, and the mixture stirred at ambient temperature for 16 h. The mixture was concentrated by rotary evaporator, diluted with EtOAc (600 mL), then washed sequentially with water (2×), aqueous NaHCO3 (2×) and brine (2×) and dried (Na2SO4). Solvent removal gave a red-brown oil which was purified by column chromatography on silica gel, eluting with 0-70% EtOAc/hexanes to provide 6.55 g of product.
Workup
- concentrationThe mixture was concentrated by rotary evaporator
- additiondiluted with EtOAc (600 mL)
- washwashed sequentially with water (2×), aqueous NaHCO3 (2×) and brine (2×)
- dry with materialdried (Na2SO4)
- customSolvent removal
- customgave a red-brown oil which
- customwas purified by column chromatography on silica gel
- washeluting with 0-70% EtOAc/hexanes
Sources & evidence
- ORD record
- ord-71498c06e52d4322888d5d022d204835
- Source dataset
- uspto-grants-2010_08
- Patent number
- US07772231B2
Reaction notes
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