Acetic Anhydride → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

HRID 501236Notes

Reaction equation

HRID 501236 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.Cl.[NH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1.C(OCC)(=O)C>C(N(CC)CC)C>[CH2:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:18][CH:10]1[NH:9][C:5](=[O:7])[CH3:6]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 1227642-Aminoindan hydrochloride

Product 1

HCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Acetic anhydride (3.55 ml) was dropped to the mixture of 6.37 g 2-amino indane hydrochloride, 60 ml of ethyl acetate and 10.4 ml triethylamine and the reaction mixture was stirred at room temperature for 15 hours. The solvents were evaporated in vacuo and the solid residue was digested with water, filtered and dried at 40° C. in vacuo.

Workup

  1. customThe solvents were evaporated in vacuo
  2. filtrationfiltered
  3. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-c7d4fc384e50469a9368bf8d6b2505af
Source dataset
uspto-grants-2010_08
Patent number
US07772257B2

Reaction notes

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