Methane → HCID 68461035, compound

HRID 501492Notes

Reaction equation

HRID 501492 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH:17]([C:18]([OH:20])=[O:19])[CH2:16][CH:15]3[CH2:21][CH2:22][CH2:23][CH:14]23)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.C>CN(C=O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH:17]([C:18]([OH:20])=[O:19])[CH2:16][CH:15]3[CH2:21][CH2:22][CH2:23][CH:14]23)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 297MethaneHCID 68459735HCID 68459735, compound

Product 1

HCID 68461035HCID 68461035, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

1 g of 1-(4-nitrobenzenesulfonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid (14) was dissolved in 15 ml of DMF, after which 0.1 g of hydrogenation catalyst (10% Pd on active charcoal) was added and the starting compound was quantitatively hydrogenated within 2 h. After the solvent had been removed, the crude product was purified chromatographically.

Workup

  1. customAfter the solvent had been removed
  2. customthe crude product was purified chromatographically

Sources & evidence

ORD record
ord-242e08dc46fb43368b8a8ebbe9b17df1
Source dataset
uspto-grants-2010_08
Patent number
US07772270B2

Reaction notes

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