Potassium Carbonate → HCID 2320680, compound

HRID 502649Notes

Reaction equation

HRID 502649 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH2:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH3:12].C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([C:6]([C:5]2[CH:9]=[CH:10][C:2]([I:1])=[CH:3][CH:4]=2)=[O:7])[CH2:15][CH2:14]1)[CH3:12]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 743734-Iodobenzoyl chlorideHCID 791961-Ethylpiperazine

Product 1

HCID 2320680HCID 2320680, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a 100 mL round bottom flask was placed 4-iodobenzoyl chloride (2.67 g, 0.01 mmol) and dichloromethane (25 mL). The flask was placed in an ice water bath. Then N-ethylpiperazine (2.6 mL, 0.021 mmol) was added dropwise with stirring. The reaction was allowed to stir for 10 days at room temperature. Saturated aqueous potassium carbonate (50 mL) was added, and the product was extracted with ethyl acetate (3×100 mL). The organic layers were dried over sodium sulfate, filtered through a silica plug, and concentrated under reduced pressure to afford the title compound as a yellow oil. Mass found by LC-MS(+): 345 M+H+); calc. for C19H29BN2O3: 344.26.

Workup

  1. customInto a 100 mL round bottom flask was placed
  2. customThe flask was placed in an ice water bath
  3. stirringto stir for 10 days at room temperature
  4. extractionthe product was extracted with ethyl acetate (3×100 mL)
  5. dry with materialThe organic layers were dried over sodium sulfate
  6. filtrationfiltered through a silica plug
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-46cf81e10ff14f108c5b2d940e3369b5
Source dataset
uspto-grants-2010_08
Patent number
US07776867B2

Reaction notes

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