HCID 13683465, compound → HCID 68468755, compound

HRID 502969Notes

Reaction equation

HRID 502969 reaction equation
[CH2:1]([Li])CCC.[CH3:6][C:7]([CH3:23])([C:15](=O)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1COCC1>[CH3:6][C:7]([CH3:23])([C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:1])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]

Participants

5

Reactant 2

HCID 13683465HCID 13683465, compoundHCID 178418339Butyllithium

Product 1

HCID 68468755HCID 68468755, compound

Reagents, catalysts & solvents 2

HCID 74505Methyltriphenyliphosphonium bromideCatalystHCID 8028TetrahydrofuranSolvent2×

Procedure

After methyltriphenylphosphonium bromide and n-butyllithium were reacted in THF, a THF solution of tert-butyl 2,2-dimethyl-3-oxo-3-phenylpropanoate was added thereto and the whole was reacted under heating to obtain tert-butyl 2,2-dimethyl-3-phenylbut-3-enoate.

Workup

  1. customthe whole was reacted
  2. temperatureunder heating

Sources & evidence

ORD record
ord-ed02ba113d154f4d992de851b6f3065f
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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