反应详情

To a solution of 50 mg of tert-butyl 5-amino-3-(3-fluorophenyl)-1H-1-indazolecarboxylate produced in Production Example I-26 in 5 ml tetrahydrofuran was added 0.015 ml of ethyl isocyanate, and the mixture was stirred at room temperature for 2 hours. After the completion of the reaction, to the reaction mixture was added with 1 ml of 5 N hydrochloric acid and the mixture was stirred for further 1 hour. To the reaction mixture was added an aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The extract was sequentially washed with water, dried over anhydrous magnesium sulfate and the solvent was evaporated. To the residue was added diisopropyl ether, and the mixture was filtered, to give 28 mg of the title compound as a colorless powder.

1. customAfter the completion of the reaction
2. stirringthe mixture was stirred for further 1 hour
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was sequentially washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. additionTo the residue was added diisopropyl ether
8. filtrationthe mixture was filtered