N-bromobutanimide → 4-(3-Bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

HRID 503734ノート

反応式

HRID 503734 の反応式
[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C(=O)N([Br:31])C(=O)C1>C(Cl)(Cl)Cl>[Br:31][C:13]1[N:11]2[CH:12]=[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:8]([C:16]3[CH:17]=[CH:18][C:19]([CH:20]=[O:21])=[CH:22][CH:23]=3)=[N:9][C:10]2=[N:15][CH:14]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 866306554-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

生成物 1

HCID 866306584-(3-Bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

1.5 g 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described under example 1) and 0.9 g NBS are refluxed in 30 ml chloroform for 1 h. The solvent is removed by distillation and the crude product is purified by column chromatography (dichloromethane/methanol).

後処理

  1. customThe solvent is removed by distillation
  2. customthe crude product is purified by column chromatography (dichloromethane/methanol)

出典と根拠

ORDレコード
ord-37feae7cdef94c4984893af73bece249
出典データセット
uspto-grants-2010_08
特許番号
US07776864B2

反応ノート

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