反应详情

499 mg of 4-ethoxyphenylacetic acid ethyl ester, 480 mg of carbonyldiimidazole, and 0.5 g of 4-methanesulfonyl benzoic acid were dissolved in 10 ml of dimethy formamide, and 119 mg of sodium hydride were slowly added dropwise to the solution and the mixture was reacted at the room temperature for 12 hours. Afterwards, water was added to dilute the resultant, followed by extraction with ethyl acetate. The obtained organic layer was dried over anhydrous magnesium sulfate to give 0.9 g of the titled compound as a light yellow liquid (yield 92%).

1. customthe mixture was reacted at the room temperature for 12 hours
2. additionto dilute the resultant
3. extractionfollowed by extraction with ethyl acetate
4. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate