Hydrochloric Acid → HCID 178510195, compound

HRID 505911Notes

Reaction equation

HRID 505911 reaction equation
FC(F)(F)C([NH:5][CH2:6][C:7]1[CH:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)=[CH:14][CH:13]=2)[CH:8]=1)=O.[OH-].[Li+].Cl>O1CCCC1.O>[NH2:5][CH2:6][C:7]1[CH:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)=[CH:14][CH:13]=2)[CH:8]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178513617HCID 178513617, compound

Product 1

HCID 178510195HCID 178510195, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

1.7 g (4 mmol) of the compound from Example 24 were dissolved in 70 ml of tetrahydrofuran and admixed with a solution of 0.38 g (15.9 mmol) of lithium hydroxide in 25 ml of water. The entire mixture was stirred at room temperature for 2 hours. The reaction mixture was then neutralized using dilute hydrochloric acid and the organic solvent was removed under reduced pressure. The resulting precipitate was filtered off with suction and dried. This gives 0.87 g of the product.

Workup

  1. customthe organic solvent was removed under reduced pressure
  2. filtrationThe resulting precipitate was filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-6d0bfc9c48924e19ac5afb05c9deb6c5
Source dataset
uspto-grants-2010_08
Patent number
US07781596B1

Reaction notes

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