Hydrochloric Acid → HCID 178510196, compound

HRID 505914Notes

Reaction equation

HRID 505914 reaction equation
FC(F)(F)C([NH:5][CH2:6][C:7]1[CH:11]=[CH:10][N:9]([C:12]2[CH:13]=[C:14]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:15]=[CH:16][CH:17]=2)[CH:8]=1)=O.[OH-].[Li+].Cl>O1CCCC1.O>[NH2:5][CH2:6][C:7]1[CH:11]=[CH:10][N:9]([C:12]2[CH:13]=[C:14]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:15]=[CH:16][CH:17]=2)[CH:8]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178513616HCID 178513616, compound

Product 1

HCID 178510196HCID 178510196, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

2.3 g (5.4 mmol) of the compound from Example 29 were dissolved in 100 ml of tetrahydrofuran and mixed with 0.26 g (10.8 mmol) of lithium hydroxide, dissolved in 50 ml of water. The entire mixture was stirred at room temperature for 2 hours. The mixture was subsequently neutralized by addition of dilute hydrochloric acid and the organic solvent was removed under reduced pressure. The precipitate, which slowly crystallized out, was filtered off with suction. This gave 0.61 g of the product.

Workup

  1. customthe organic solvent was removed under reduced pressure
  2. customThe precipitate, which slowly crystallized out
  3. filtrationwas filtered off with suction

Sources & evidence

ORD record
ord-9600a1cccae24d3bac856931ba43ab49
Source dataset
uspto-grants-2010_08
Patent number
US07781596B1

Reaction notes

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