Nitrate → 3-Iodo-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

HRID 506617Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=2)[CH:7]=[CH:6][CH:5]=1.C(I)[I:19].[N+]([O-])([O-])=O>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=2)[CH:7]=[C:6]([I:19])[CH:5]=1

Participants

Reactant 3

HCID 943Nitrate

HCID 6346Diiodomethane

HCID 58326661HCID 58326661, compound

Product 1

HCID 594325793-Iodo-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

Procedure

5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester was treated with methylene iodide and isoamy nitrate using the procedure of step 5 of preparation 6, to afford 3-iodo-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester, MS (M+H)=353.

Workup

customthe procedure of step 5 of preparation 6

Sources & evidence

ORD record: ord-80085afea49e4dfa89bcc857df303126
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07786110B2

Reaction notes

Loading…