Hydrochloric Acid → HCID 22964513, compound

HRID 506860Notes

Reaction equation

HRID 506860 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[CH3:18][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59432792HCID 59432792, compound

Product 1

HCID 22964513HCID 22964513, compoundYield 135.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(methyl-propyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (106 mg, 0.41 mmol) in AcOEt (10 ml) was added 3N HCl (4 ml). The reaction mixture was stirred for 16 hrs at RT. The solvent was removed under reduced pressure to give the desired methyl-piperidin-4-yl-propyl-amine (87 mg, 92% yield).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3b395b38d67c407eadb1c20f3c55d2a0
Source dataset
uspto-grants-2010_08
Patent number
US07786121B2

Reaction notes

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