反应详情

To a solution of compound 13 (6.14 g, 20 mmol) in THF (50 mL), 3N LiOH solution (20 mL, 60 mmol) was added. After stirring for 1 h, the resulting mixture was adjusted to pH=5-6 using 1N HCl, and extracted with ethyl acetate. The combined organic phases were concentrated to afford compound 14 (5.6 g, 95.6%). 1H NMR (400 MHz, CDCl3) δ 1.43 (s, 9 H), 2.85-2.87 (m, 1 H), 3.17-3.19 (m, 1 H), 5.74-6.11 (bs, 2 H), 7.34-7.46 (m, 5 H).

1. extractionextracted with ethyl acetate
2. concentrationThe combined organic phases were concentrated